The Biology of Cancer Exosomes: Insights and New Perspectives
Universidade do Porto · i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto · +1 more institution
Abstract
Abstract Exosomes are a subclass of extracellular vesicles involved in intercellular communication that are released by all cell types, including cancer cells. Cancer exosomes carry malignant information in the form of proteins, lipids, and nucleic acids that can reprogram recipient cells. Exosomes have emerged as putative biological mediators in cancer contributing to major steps of disease progression. A leading role exists for cancer exosomes in specific aspects of tumor progression: modulation of immune response, tumor microenvironment reprogramming, and metastasis. This review will address the functions attributed to cancer exosomes in these three aspects of cancer biology, highlighting recent advances…
Citation impact
- FWCI
- 23.32
- Percentile
- 100%
- References
- 86
Authors
4- CFCarolina F. RuivoCorresponding
Universidade do Porto, i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
- BABárbara Adem
Universidade do Porto, i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
- MGMiguel G. Silva
Universidade do Porto, TUM Klinikum, i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
- SASónia A. Melo
Universidade do Porto, i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
Topics & keywords
- Microvesicles
- Cancer
- Reprogramming
- Biology
- Metastasis
- Immune system
- Tumor microenvironment
- Cancer cell
- Good health and well-being