Zinc-finger proteins in health and disease

Cassandri, Matteo; Smirnov, Artem; Novelli, Flavia; Pitolli, Consuelo; Agostini, Massimiliano; Malewicz, Michal; Melino, Gerry; Raschellà, Giuseppe

doi:10.1038/cddiscovery.2017.71

reviewCell Death DiscoveryNov 13, 2017GOLD OA

Zinc-finger proteins in health and disease

MCMatteo Cassandri ASArtem Smirnov FNFlavia Novelli CPConsuelo Pitolli MAMassimiliano Agostini

University of Rome Tor Vergata · University of Leicester · +2 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

Zinc-finger proteins (ZNFs) are one of the most abundant groups of proteins and have a wide range of molecular functions. Given the wide variety of zinc-finger domains, ZNFs are able to interact with DNA, RNA, PAR (poly-ADP-ribose) and other proteins. Thus, ZNFs are involved in the regulation of several cellular processes. In fact, ZNFs are implicated in transcriptional regulation, ubiquitin-mediated protein degradation, signal transduction, actin targeting, DNA repair, cell migration, and numerous other processes. The aim of this review is to provide a comprehensive summary of the current state of knowledge of this class of proteins. Firstly, we describe the actual classification of ZNFs, their structure and…

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Topics & keywords

Topics

Keywords

Zinc finger
Zinc
Zinc finger nuclease
Disease
Medicine
Biology
Genetics
Chemistry

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