Cancer nanomedicine: a review of recent success in drug delivery

Abstract Cancer continues to be one of the most difficult global healthcare problems. Although there is a large library of drugs that can be used in cancer treatment, the problem is selectively killing all the cancer cells while reducing collateral toxicity to healthy cells. There are several biological barriers to effective drug delivery in cancer such as renal, hepatic, or immune clearance. Nanoparticles loaded with drugs can be designed to overcome these biological barriers to improve efficacy while reducing morbidity. Nanomedicine has ushered in a new era for drug delivery by improving the therapeutic indices of the active pharmaceutical ingredients engineered within nanoparticles. First generation…

• NI
  National Institutes of Health

  Awards: K99CA153948, R00CA153948
• NC
  National Cancer Institute

  Awards: K99CA153948, R00CA153948