Sperm-Hybrid Micromotor for Targeted Drug Delivery
Leibniz Institute for Solid State and Materials Research · Chemnitz University of Technology
Abstract
A sperm-driven micromotor is presented as a targeted drug delivery system, which is appealing to potentially treat diseases in the female reproductive tract. This system is demonstrated to be an efficient drug delivery vehicle by first loading a motile sperm cell with an anticancer drug (doxorubicin hydrochloride), guiding it magnetically, to an in vitro cultured tumor spheroid, and finally freeing the sperm cell to deliver the drug locally. The sperm release mechanism is designed to liberate the sperm when the biohybrid micromotor hits the tumor walls, allowing it to swim into the tumor and deliver the drug through the sperm-cancer cell membrane fusion. In our experiments, the sperm cells exhibited a high…
Citation impact
- FWCI
- 31.63
- Percentile
- 100%
- References
- 71
Authors
6- HXHaifeng XuCorresponding
Leibniz Institute for Solid State and Materials Research
- MMMariana Medina‐Sánchez
Leibniz Institute for Solid State and Materials Research
- VMVeronika Magdanz
Leibniz Institute for Solid State and Materials Research
- LSLukas Schwarz
Leibniz Institute for Solid State and Materials Research
- FHFranziska Hebenstreit
Leibniz Institute for Solid State and Materials Research
Topics & keywords
- Sperm
- Drug delivery
- Nanotechnology
- Cell biology
- Drug
- Microcarrier
- Biomedical engineering
- Materials science
- Good health and well-being