reviewEssays in BiochemistryDec 12, 2017HYBRID OA

mTORC1 as the main gateway to autophagy

YRYoana Rabanal‐RuizEGElsje G. OttenVIViktor I. Korolchuk

Newcastle University

PubMed
Indexed incrossrefpubmed

Abstract

Cells and organisms must coordinate their metabolic activity with changes in their environment to ensure their growth only when conditions are favourable. In order to maintain cellular homoeostasis, a tight regulation between the synthesis and degradation of cellular components is essential. At the epicentre of the cellular nutrient sensing is the mechanistic target of rapamycin complex 1 (mTORC1) which connects environmental cues, including nutrient and growth factor availability as well as stress, to metabolic processes in order to preserve cellular homoeostasis. Under nutrient-rich conditions mTORC1 promotes cell growth by stimulating biosynthetic pathways, including synthesis of proteins, lipids and…

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Authors

3

Topics & keywords

Topics
Keywords
  • mTORC1
  • Autophagy
  • Catabolism
  • Cell biology
  • Nutrient sensing
  • Biology
  • AMPK
  • Metabolic pathway
UN Sustainable Development Goals
  • Affordable and clean energy
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