Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex
University of California, San Francisco · Broad Center · +2 more institutions
Abstract
Systematic analyses of spatiotemporal gene expression trajectories during organogenesis have been challenging because diverse cell types at different stages of maturation and differentiation coexist in the emerging tissues. We identified discrete cell types as well as temporally and spatially restricted trajectories of radial glia maturation and neurogenesis in developing human telencephalon. These lineage-specific trajectories reveal the expression of neurogenic transcription factors in early radial glia and enriched activation of mammalian target of rapamycin signaling in outer radial glia. Across cortical areas, modest transcriptional differences among radial glia cascade into robust typological…
Citation impact
- FWCI
- 34.31
- Percentile
- 100%
- References
- 38
Authors
18- TJTomasz J. NowakowskiCorresponding
University of California, San Francisco, Broad Center
- ABAparna BhaduriCorresponding
University of California, San Francisco, Broad Center
- AAAlex A. PollenCorresponding
University of California, San Francisco, Broad Center
- BABeatriz Alvarado
University of California, San Francisco, Broad Center
- MAMohammed A. Mostajo-Radji
University of California, San Francisco, Broad Center
Topics & keywords
- Cerebrum
- Biology
- Neuroscience
- Neurogenesis
- Cell type
- Transcription factor
- Cerebral cortex
- Cortex (anatomy)
- Sustainable cities and communities