Mitochondrial metabolism and cancer

Glycolysis has long been considered as the major metabolic process for energy production and anabolic growth in cancer cells. Although such a view has been instrumental for the development of powerful imaging tools that are still used in the clinics, it is now clear that mitochondria play a key role in oncogenesis. Besides exerting central bioenergetic functions, mitochondria provide indeed building blocks for tumor anabolism, control redox and calcium homeostasis, participate in transcriptional regulation, and govern cell death. Thus, mitochondria constitute promising targets for the development of novel anticancer agents. However, tumors arise, progress, and respond to therapy in the context of an intimate…

• AP
  Association pour la Recherche sur le Cancer
• E
  E-Rare
• EC
  European Commission
• AN
  Agence Nationale de la Recherche

  Award: E-Rare-2
• FL
  Fondation Leducq
• FC
  Fondazione Cariplo

  Award: 2015-0634
• FP
  Fondation pour la Recherche Médicale
• MD
  Ministero dell’Istruzione, dell’Università e della Ricerca
• LC
  Ligue Contre le Cancer
• IU
  Institut Universitaire de France
• IN
  Institut National Du Cancer
• WC
  Weill Cornell Medical College
• LI
  Labex Immuno-Oncology