reviewThe Journal of Cell BiologyDec 12, 2017BRONZE OA

Rho GTPase signaling complexes in cell migration and invasion

CDCampbell D. LawsonAJAnne J. Ridley

King's College London

PubMed
Indexed incrossrefpubmed

Abstract

Cell migration is dependent on the dynamic formation and disassembly of actin filament-based structures, including lamellipodia, filopodia, invadopodia, and membrane blebs, as well as on cell-cell and cell-extracellular matrix adhesions. These processes all involve Rho family small guanosine triphosphatases (GTPases), which are regulated by the opposing actions of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Rho GTPase activity needs to be precisely tuned at distinct cellular locations to enable cells to move in response to different environments and stimuli. In this review, we focus on the ability of RhoGEFs and RhoGAPs to form complexes with diverse binding partners, and…

Citation impact

548
total citations
FWCI
19.29
Percentile
100%
References
111
Citations per year

Authors

2

Topics & keywords

Topics
Keywords
  • GTPase
  • Guanine nucleotide exchange factor
  • Lamellipodium
  • Filopodia
  • Cell biology
  • Cell migration
  • Context (archaeology)
  • Extracellular matrix
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