Current and future therapeutic approaches for osteosarcoma
The University of Texas MD Anderson Cancer Center · Albert Einstein College of Medicine · +2 more institutions
Abstract
INTRODUCTION: Current treatment of osteosarcoma includes surgical resection of all gross disease in conjunction with systemic chemotherapy to control micro-metastatic disease. This yields a 5-year event free survival (EFS) of approximately 70% for patients with localized osteosarcoma while patients with metastatic or recurrent disease fare poorly with overall survival rates of less than 20%. Areas covered: This review outlines the current and future approach towards the treatment of osteosarcoma. A literature search was performed utilizing PubMed. Several recent clinical trials are reviewed in detail, as is innovative research evaluating novel agents and surgical techniques which hold promise. Expert…
Citation impact
- FWCI
- 42.23
- Percentile
- 100%
- References
- 105
Authors
5- DJDouglas J. HarrisonCorresponding
The University of Texas MD Anderson Cancer Center
- DSDavid S. Geller
Albert Einstein College of Medicine, Children's Hospital at Montefiore, Montefiore Medical Center
- JGJonathan Gill
The University of Texas MD Anderson Cancer Center
- VOValerae O. Lewis
The University of Texas MD Anderson Cancer Center
- RGRichard Görlick
The University of Texas MD Anderson Cancer Center
Topics & keywords
- Osteosarcoma
- Medicine
- Disease
- Population
- Intensive care medicine
- Clinical trial
- Oncology
- Internal medicine