reviewBosnian Journal of Basic Medical SciencesDec 23, 2017GOLD OA

The role of the Hedgehog signaling pathway in cancer: A comprehensive review

AMAna Marija ŠkodaDSDora SimovicVKValentina Karin‐KujundžićVKVedran KardumSVSemir Vranić

University of Zagreb · Klinička bolnica Merkur · +1 more institution

PubMed
Indexed incrossrefdoajpubmed

Abstract

The Hedgehog (Hh) signaling pathway was first identified in the common fruit fly. It is a highly conserved evolutionary pathway of signal transmission from the cell membrane to the nucleus. The Hh signaling pathway plays an important role in the embryonic development. It exerts its biological effects through a signaling cascade that culminates in a change of balance between activator and repressor forms of glioma-associated oncogene (Gli) transcription factors. The components of the Hh signaling pathway involved in the signaling transfer to the Gli transcription factors include Hedgehog ligands (Sonic Hh [SHh], Indian Hh [IHh], and Desert Hh [DHh]), Patched receptor (Ptch1, Ptch2), Smoothened receptor (Smo),…

Citation impact

787
total citations
FWCI
13.34
Percentile
100%
References
162
Citations per year

Authors

6

Topics & keywords

Topics
Keywords
  • Smoothened
  • GLI1
  • Hedgehog signaling pathway
  • Hedgehog
  • Signal transduction
  • Cancer research
  • Patched
  • Autocrine signalling
UN Sustainable Development Goals
  • Good health and well-being
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