Oxygen Activation and Radical Transformations in Heme Proteins and Metalloporphyrins

Activation processes mediated by heme proteins and model compounds with a focus on recent progress in the characterization and reactivity of important iron-oxygen intermediates. Representative reactions initiated by these reactive intermediates as well as some context from prior decades will also be presented. We will discuss the fundamental mechanistic features of these transformations and delineate the underlying structural and electronic factors that contribute to the spectrum of reactivities that has been observed in nature as well as those that have been invented using these paradigms. Given the recent developments in biocatalysis for non-natural chemistries and the renaissance of radical chemistry in…

• M
  Merck
• NI
  National Institute of General Medical Sciences

  Award: F32 GM125231
• DO
  Division of Chemistry

  Awards: CHE-1464578, CHE-1148597
• BE
  Basic Energy Sciences

  Award: DE-SC0001298