Coronary microvascular dysfunction and future risk of heart failure with preserved ejection fraction
Brigham and Women's Hospital · Harvard University · +1 more institution
Abstract
Coronary microvascular ischaemia, cardiomyocyte injury and stiffness may play an important role in the pathophysiology of heart failure with preserved ejection fraction (HFpEF). To date, the relationship between coronary flow reserve (CFR), myocardial injury, diastolic dysfunction, and future HFpEF risk is unknown. Consecutive patients (n = 201) undergoing evaluation for suspected coronary artery disease (CAD) with stress myocardial perfusion positron emission tomography, serum troponin, and transthoracic echocardiography who did not have flow-limiting CAD or reduced left ventricular ejection fraction were identified. Patients were followed up (median 4.1 years) for cardiovascular death and hospitalization for…
Citation impact
- FWCI
- 30.48
- Percentile
- 100%
- References
- 37
Authors
11- VRViviany R. TaquetiCorresponding
Brigham and Women's Hospital, Harvard University
- SDScott D. Solomon
Brigham and Women's Hospital, Harvard University
- AMAmil M. Shah
Harvard University, Brigham and Women's Hospital
- ASAkshay S. Desai
Harvard University, Brigham and Women's Hospital
- JDJohn D. Groarke
Brigham and Women's Hospital, Harvard University
Topics & keywords
- Medicine
- Cardiology
- Internal medicine
- Ejection fraction
- Coronary flow reserve
- Diastole
- Heart failure
- Heart failure with preserved ejection fraction
- Good health and well-being