reviewImmunological ReviewsDec 16, 2017HYBRID OA

Interleukin‐33 ( IL ‐33): A nuclear cytokine from the IL ‐1 family

CCCorinne CayrolJGJean‐Philippe Girard

Centre National de la Recherche Scientifique · Université Toulouse III - Paul Sabatier · +2 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Summary Interleukin‐33 ( IL ‐33) is a tissue‐derived nuclear cytokine from the IL ‐1 family abundantly expressed in endothelial cells, epithelial cells and fibroblast‐like cells, both during homeostasis and inflammation. It functions as an alarm signal (alarmin) released upon cell injury or tissue damage to alert immune cells expressing the ST 2 receptor ( IL ‐1 RL 1). The major targets of IL ‐33 in vivo are tissue‐resident immune cells such as mast cells, group 2 innate lymphoid cells ( ILC 2s) and regulatory T cells (Tregs). Other cellular targets include T helper 2 (Th2) cells, eosinophils, basophils, dendritic cells, Th1 cells, CD 8 + T cells, NK cells, iNKT cells, B cells, neutrophils and macrophages. IL…

Citation impact

847
total citations
FWCI
23.21
Percentile
100%
References
150
Citations per year

Authors

2

Topics & keywords

Topics
Keywords
  • Cytokine
  • Biology
  • Interleukin 15
  • Immunology
  • Interleukin
  • Molecular biology
UN Sustainable Development Goals
  • Good health and well-being
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