The ACE2/Angiotensin-(1–7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1–7)
Universidade Federal de Ouro Preto · German Centre for Cardiovascular Research · +1 more institution
Abstract
The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular system and hydroelectrolyte balance, with an influence on organs and functions throughout the body. The classical view of this system saw it as a sequence of many enzymatic steps that culminate in the production of a single biologically active metabolite, the octapeptide angiotensin (ANG) II, by the angiotensin converting enzyme (ACE). The past two decades have revealed new functions for some of the intermediate products, beyond their roles as substrates along the classical route. They may be processed in alternative ways by enzymes such as the ACE homolog ACE2. One effect is to establish a second axis through…
Citation impact
- FWCI
- 58.43
- Percentile
- 100%
- References
- 644
Authors
7- RARobson A.S. SantosCorresponding
Universidade Federal de Ouro Preto, German Centre for Cardiovascular Research, Berlin Institute of Health at Charité - Universitätsmedizin Berlin
- WOWalkyria Oliveira Sampaio
Universidade Federal de Ouro Preto, German Centre for Cardiovascular Research, Berlin Institute of Health at Charité - Universitätsmedizin Berlin
- ACAndréia Carvalho Alzamora
Universidade Federal de Ouro Preto, German Centre for Cardiovascular Research, Berlin Institute of Health at Charité - Universitätsmedizin Berlin
- DMDaisy Motta‐Santos
Universidade Federal de Ouro Preto, German Centre for Cardiovascular Research, Berlin Institute of Health at Charité - Universitätsmedizin Berlin
- NANatália Alenina
Universidade Federal de Ouro Preto, German Centre for Cardiovascular Research, Berlin Institute of Health at Charité - Universitätsmedizin Berlin
Topics & keywords
- Renin–angiotensin system
- Angiotensin II
- Focus (optics)
- Angiotensin 1
- Internal medicine
- Endocrinology
- Medicine
- Receptor