Nanozyme Decorated Metal–Organic Frameworks for Enhanced Photodynamic Therapy
Chinese Academy of Sciences · Changchun Institute of Applied Chemistry · +3 more institutions
Abstract
Metal–organic frameworks (MOFs) have been used for photodynamic therapy (PDT) of cancers by integrating photosensitizers, which cause cytotoxic effects on cancer cells by converting tumor oxygen into reactive singlet oxygen (1O2). However, the PDT efficiency of MOFs is severely limited by tumor hypoxia. Herein, by decorating platinum nanozymes on photosensitizer integrated MOFs, we report a simple yet versatile strategy for enhanced PDT. The platinum nanoparticles homogeneously immobilized on MOFs possess high stability and catalase-like activity. Thus, our nanoplatform can facilitate the formation of 1O2 in hypoxic tumor site via H2O2-activated evolvement of O2, which can cause more serious damage to cancer…
Citation impact
- FWCI
- 36.34
- Percentile
- 100%
- References
- 53
Authors
9- YZYan ZhangCorresponding
Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, University of Chinese Academy of Sciences
- FWFaming Wang
Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, University of Chinese Academy of Sciences
- CLChaoqun Liu
Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, University of Chinese Academy of Sciences
- ZWZhenzhen Wang
Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, University of Chinese Academy of Sciences
- LKLihua Kang
Jilin University, First Hospital of Jilin University
Topics & keywords
- Photodynamic therapy
- Metal-organic framework
- Materials science
- Nanotechnology
- Chemistry
- Adsorption
- Organic chemistry