Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner
Centre National de la Recherche Scientifique · Inserm · +15 more institutions
Abstract
Microglia are embryonically seeded macrophages that contribute to brain development, homeostasis, and pathologies. It is thus essential to decipher how microglial properties are temporally regulated by intrinsic and extrinsic factors, such as sexual identity and the microbiome. Here, we found that microglia undergo differentiation phases, discernable by transcriptomic signatures and chromatin accessibility landscapes, which can diverge in adult males and females. Remarkably, the absence of microbiome in germ-free mice had a time and sexually dimorphic impact both prenatally and postnatally: microglia were more profoundly perturbed in male embryos and female adults. Antibiotic treatment of adult mice triggered…
Citation impact
- FWCI
- 35.42
- Percentile
- 100%
- References
- 82
Authors
30- MSMorgane Sonia ThionCorresponding
Centre National de la Recherche Scientifique, Inserm, École Normale Supérieure - PSL, Institut de Biologie de l'École Normale Supérieure
- DLDonovan Low
Agency for Science, Technology and Research, Singapore Immunology Network
- ASAymeric Silvin
Agency for Science, Technology and Research, Singapore Immunology Network
- JCJinmiao Chen
Agency for Science, Technology and Research, Singapore Immunology Network
- PGPauline Grisel
Centre National de la Recherche Scientifique, Inserm, École Normale Supérieure - PSL, Institut de Biologie de l'École Normale Supérieure
Topics & keywords
- Microglia
- Biology
- Transcriptome
- Microbiome
- Immunology
- Neuroscience
- Bioinformatics
- Inflammation
Funding
- DFDeutsche ForschungsgemeinschaftAwards: SFB704, SCHL 2116/1-1
- ANAgence Nationale de la Recherche
- INInstitut National de la Santé et de la Recherche Médicale
- MOMinistry of the Environment, Government of JapanAward: Tier1
- BFBundesministerium für Wirtschaft und Energie
- CNConseil National de la Recherche Scientifique