Potential of long non‐coding RNAs in cancer patients: From biomarkers to therapeutic targets

Because of high specificity and easy detection in the tissues, serum, plasma, urine and saliva, interest in exploring the potential of long non-coding RNAs (lncRNAs) in cancer patients continues to increase. LncRNAs have shown potential as a biomarker in the diagnosis and prognosis of bladder cancer, prostate cancer, gastric cancer, pancreatic cancer, breast cancer and many other cancer types. Some lncRNAs have also been used as adjunct to improve the specificity and sensitivity of existing biomarkers. The molecular tools such as RNA-seq, RNA-FISH, ic-SHAPE and quantitative real-time PCR have been used for examining the lncRNAs' potential. Some lncRNAs such as PCA3 is now routinely used in the clinic for the…

• UG
  University Grants Commission

  Award: ECR/2016/000034
• BH
  Banaras Hindu University

  Award: 2015-16/608
• SA
  Science and Engineering Research Board

  Awards: 2016/000034, ECR/2016/000034