A multicentre study of antifungal susceptibility patterns among 350 Candida auris isolates (2009–17) in India: role of the ERG11 and FKS1 genes in azole and echinocandin resistance

Chowdhary, Anuradha; Prakash, Anupam; Sharma, Cheshta; Kordalewska, Milena; Kumar, Anil; Sarma, Smita; Tarai, Bansidhar; Singh, Ashutosh; Upadhyaya, Gargi; Upadhyay, Shalini; Yadav, Priyanka; Singh, Pradeep Kumar; Khillan, Vikas; Sachdeva, Neelam; Perlin, David S.; Meis, Jacques F.

doi:10.1093/jac/dkx480

articleJournal of Antimicrobial ChemotherapyNov 22, 2017BRONZE OA

A multicentre study of antifungal susceptibility patterns among 350 Candida auris isolates (2009–17) in India: role of the ERG11 and FKS1 genes in azole and echinocandin resistance

ACAnuradha Chowdhary APAnupam Prakash CSCheshta Sharma MKMilena Kordalewska AKAnil Kumar

University of Delhi · Rutgers, The State University of New Jersey · +10 more institutions

PubMed

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Abstract

Background

Candida auris has emerged globally as an MDR nosocomial pathogen in ICU patients.

Objectives

We studied the antifungal susceptibility of C. auris isolates (n = 350) from 10 hospitals in India collected over a period of 8 years. To investigate azole resistance, ERG11 gene sequencing and expression profiling was conducted. In addition, echinocandin resistance linked to mutations in the C. auris FKS1 gene was analysed.

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577

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FWCI: 29.11
Percentile: 100%
References: 44

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Authors

16

Topics & keywords

Topics

Keywords

Echinocandin
Candida auris
Fluconazole
Flucytosine
Microbiology
Echinocandins
Biology
Amphotericin B

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