Structural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study

Progressive functional decline in the epilepsies is largely unexplained. We formed the ENIGMA-Epilepsy consortium to understand factors that influence brain measures in epilepsy, pooling data from 24 research centres in 14 countries across Europe, North and South America, Asia, and Australia. Structural brain measures were extracted from MRI brain scans across 2149 individuals with epilepsy, divided into four epilepsy subgroups including idiopathic generalized epilepsies (n =367), mesial temporal lobe epilepsies with hippocampal sclerosis (MTLE; left, n = 415; right, n = 339), and all other epilepsies in aggregate (n = 1026), and compared to 1727 matched healthy controls. We ranked brain structures in order of…

• NS
  National Science Foundation

  Awards: DBI-1260795, 1531491, 1302755, 1260795, 1062057, IIS-1302755, DBI-1260795, DBI-1062057, CNS-1531491, IIS-1302755
• OS
  Ohio State University
• FA
  Finding A Cure for Epilepsy and Seizures
• IY
  Itä-Suomen Yliopisto
• UD
  Università Degli Studi di Modena e Reggio Emila
• SL
  South London and Maudsley NHS Foundation Trust
• HA
  Health and Care Research Wales
• NB
  NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research
• MA
  Morris and Alma Schapiro Fund
• NI
  National Institute for Health and Care Research

  Award: U54 EB020403
• ER
  Epilepsy Research UK
• KC
  King's College London
• EC
  European Commission

  Awards: U54 EB020403, 602531
• UO
  University of Liverpool
• CU
  Cardiff University
• SN
  Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

  Awards: 124089, 140332 and 320030-163398, 140332, 163398, 124089, U54 EB020403, 181508, 123520, 320030
• FD
  Fundação de Amparo à Pesquisa do Estado de São Paulo

  Award: 2013/07559-3
• NN
  National Natural Science Foundation of China

  Awards: 61772440, U54 EB020403
• MD
  Ministero della Salute
• KY
  Kuopion Yliopistollinen Sairaala

  Award: 5772810
• UN
  Universidad Nacional Autónoma de México

  Award: UNAM-DGAPA IB201712
• HF
  Hospital for Sick Children
• UE
  Universidade Estadual de Campinas
• UC
  University College London Hospitals NHS Foundation Trust
• XU
  Xiamen University
• RE
  Regione Emilia-Romagna
• SS
  Saastamoisen säätiö
• ES
  Epilepsy Society
• NI
  National Institutes of Health

  Awards: EB020403, R01NS065838, 57840, U54 EB020403, DBI-1062057
• SO
  School of Medicine, New York University
• UO
  University of California, San Diego
• CI
  Canadian Institutes of Health Research

  Awards: CIHR MOP-57840, MOP-123520, MOP-57840, CIHR MOP-123520, 123520, CIHR MOP-57840 and CIHR MOP-123520
• NS
  Natural Sciences and Engineering Research Council of Canada
• FD
  Fonds de Recherche du Québec - Santé

  Award: Junior 1
• MR
  Medical Research Council

  Awards: G0701310, MR/K01417X/1, MR/K013998/1, MR/N008324/1, G0901254, MR/K023152/1, MR/K023152/1, MR/L016311/1, U54 EB020403, MR/N026063/1, MR/L016311/1
• EA
  Engineering and Physical Sciences Research Council

  Award: EP/N014391/1
• NH
  National Health and Medical Research Council

  Awards: 628952, 1060312
• DG
  Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México

  Award: IB201712
• NI
  National Institute of Neurological Disorders and Stroke

  Awards: MR/K023152/1, R01NS065838