articleNature CommunicationsMar 4, 2019GOLD OA

Atypical functional connectome hierarchy in autism

SHSeok‐Jun HongRVReinder Vos de WaelRARichard A. I. BethlehemSLSara LarivièreCPCasey Paquola

Montreal Neurological Institute and Hospital · Child Mind Institute · +12 more institutions

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Abstract

Abstract One paradox of autism is the co-occurrence of deficits in sensory and higher-order socio-cognitive processing. Here, we examined whether these phenotypical patterns may relate to an overarching system-level imbalance—specifically a disruption in macroscale hierarchy affecting integration and segregation of unimodal and transmodal networks. Combining connectome gradient and stepwise connectivity analysis based on task-free functional magnetic resonance imaging (fMRI), we demonstrated atypical connectivity transitions between sensory and higher-order default mode regions in a large cohort of individuals with autism relative to typically-developing controls. Further analyses indicated that reduced…

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560
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Authors

11

Topics & keywords

Topics
Keywords
  • Autism
  • Connectome
  • Autism spectrum disorder
  • Neuroscience
  • Functional magnetic resonance imaging
  • Cognition
  • Sensory system
  • Psychology
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