Cannabinoid Ligands Targeting TRP Channels

Transient receptor potential (TRP) channels are a group of membrane proteins involved in the transduction of a plethora of chemical and physical stimuli. These channels modulate ion entry, mediating a variety of neural signaling processes implicated in the sensation of temperature, pressure, and pH, as well as smell, taste, vision, and pain perception. Many diseases involve TRP channel dysfunction, including neuropathic pain, inflammation, and respiratory disorders, and in the venture to find new treatments for these disorders, it was discovered that cannabinoids can modulate a certain subset of TRP channels. The vanilloid (TRPV), ankyrin (TRPA), and melastatin (TRPM) subfamilies were all found to contain…

• NI
  National Institute on Drug Abuse

  Award: DA003934, KO5 DA021358