Radical Prostatectomy or Watchful Waiting in Early Prostate Cancer
Örebro University Hospital · King's College London · +10 more institutions
Abstract
Radical prostatectomy reduces mortality among men with localized prostate cancer; however, important questions regarding long-term benefit remain.
Between 1989 and 1999, we randomly assigned 695 men with early prostate cancer to watchful waiting or radical prostatectomy and followed them through the end of 2012. The primary end points in the Scandinavian Prostate Cancer Group Study Number 4 (SPCG-4) were death from any cause, death from prostate cancer, and the risk of metastases. Secondary end points included the initiation of androgen-deprivation therapy.
Citation impact
- FWCI
- 113.91
- Percentile
- 100%
- References
- 19
Authors
15- ABAnna Bill‐AxelsonCorresponding
Örebro University Hospital
- LHLars Holmberg
King's College London, Karolinska Institutet, Regional Cancer Center, Regional Research Council in Uppsala-Örebro Region
- HGHans Garmo
King's College London, Karolinska Institutet, Regional Cancer Center, Regional Research Council in Uppsala-Örebro Region
- JRJennifer R. Rider
Brigham and Women's Hospital, Harvard University
- KTKimmo Taari
Helsinki University Hospital
Topics & keywords
- Watchful waiting
- Medicine
- Prostatectomy
- Prostate cancer
- Relative risk
- Androgen deprivation therapy
- Prostate
- Urology
- Good health and well-being