Parabacteroides distasonis Alleviates Obesity and Metabolic Dysfunctions via Production of Succinate and Secondary Bile Acids
Chinese Academy of Sciences · Institute of Microbiology · +3 more institutions
Abstract
We demonstrated the metabolic benefits of Parabacteroides distasonis (PD) on decreasing weight gain, hyperglycemia, and hepatic steatosis in ob/ob and high-fat diet (HFD)-fed mice. Treatment with live P. distasonis (LPD) dramatically altered the bile acid profile with elevated lithocholic acid (LCA) and ursodeoxycholic acid (UDCA) and increased the level of succinate in the gut. In vitro cultivation of PD demonstrated its capacity to transform bile acids and production of succinate. Succinate supplementation in the diet decreased hyperglycemia in ob/ob mice via the activation of intestinal gluconeogenesis (IGN). Gavage with a mixture of LCA and UDCA reduced hyperlipidemia by activating the FXR pathway and…
Citation impact
- FWCI
- 67.48
- Percentile
- 100%
- References
- 72
Authors
12- KWKai WangCorresponding
Chinese Academy of Sciences, Institute of Microbiology, China Academy of Chinese Medical Sciences, University of Chinese Academy of Sciences
- MLMingfang Liao
Chinese Academy of Sciences, Institute of Microbiology, China Academy of Chinese Medical Sciences, University of Chinese Academy of Sciences
- NZNan Zhou
Chinese Academy of Sciences, Microbiology Institute of Shaanxi, Institute of Microbiology
- BLBao Li
Chinese Academy of Sciences, Institute of Microbiology, China Academy of Chinese Medical Sciences, University of Chinese Academy of Sciences
- KMKe Ma
Chinese Academy of Sciences, Institute of Microbiology, China Academy of Chinese Medical Sciences, University of Chinese Academy of Sciences
Topics & keywords
- Obesity
- Chemistry
- Biochemistry
- Medicine
- Endocrinology