Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

Jansen, Iris E.; Savage, Jeanne E.; Watanabe, Kyoko; Bryois, Julien; Williams, Dylan M.; Steinberg, Stacy; Sealock, Julia; Karlsson, Ida; Hägg, Sara; Athanasiu, Lavinia; Voyle, Nicola; Proitsi, Petroula; Witoelar, Aree; Stringer, Sven; Aarsland, Dag; Almdahl, Ina S.; Andersen, Fred; Bergh, Sverre; Bettella, Francesco; Björnsson, Sigurbjörn; Brækhus, Anne; Bråthen, Geir; Leeuw, Christiaan de; Desikan, Rahul S.; Djurovic, Srdjan; Dumitrescu, Logan; Fladby, Tormod; Hohman, Timothy J.; Jónsson, Pálmi V.; Kiddle, Steven J.; Rongve, Arvid; Saltvedt, Ingvild; Sando, Sigrid Botne; Selbæk, Geir; Shoai, Maryam; Skene, Nathan; Snædal, Jón; Stordal, Eystein; Ulstein, Ingun; Wang, Yunpeng; White, Linda R.; Hardy, John; Hjerling‐Leffler, Jens; Sullivan, Patrick F.; Flier, Wiesje M. van der; Dobson, Richard; Davis, Lea K.; Stefánsson, Hreinn; Stefánsson, Kāri; Pedersen, Nancy L.; Ripke, Stephan; Andreassen, Ole A.; Posthuma, Daniëlle

doi:10.1038/s41588-018-0311-9

reviewNature GeneticsJan 2, 2019GREEN OA

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

IEIris E. Jansen JEJeanne E. Savage KWKyoko Watanabe JBJulien Bryois DMDylan M. Williams

Amsterdam Neuroscience · Amsterdam University Medical Centers · +35 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

No abstract available for this paper.

Citation impact

2,511

total citations

FWCI: 251.88
Percentile: 100%
References: 77

Citations per year

Authors

IE
Iris E. Jansen
Amsterdam Neuroscience, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam
JE
Jeanne E. Savage
Amsterdam Neuroscience
KW
Kyoko Watanabe
Amsterdam Neuroscience
JB
Julien Bryois
Karolinska Institutet
DM
Dylan M. Williams
Karolinska Institutet

Topics & keywords

Topics

Genetic Associations and Epidemiology100%
Alzheimer's disease research and treatments100%
Bioinformatics and Genomic Networks99%

Keywords

Biology
Mendelian randomization
Genome-wide association study
Disease
Genetics
Alzheimer's disease
Genetic association
TREM2

UN Sustainable Development Goals

Good health and well-being

No related works found for this paper.

Funding

AA
Alzheimer's Association
Awards: U01 AG016976, U01 AG032984, AG033193, U24 AG021886, ADGC-10-196728
CW
Case Western Reserve University
WT
Wellcome Trust
Awards: MR/K006584/1, 082604/2/07/Z, FP7/2007-2013
EJ
EU Joint Programme – Neurodegenerative Disease Research
Award: 237250
EF
European Federation of Pharmaceutical Industries and Associations
Awards: 115372, FP7/2007-2013
DO
Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease
UD
Université de Lille
NI
National Institute for Health and Care Research
Award: FP7/2007-2013
EC
European Commission
Awards: FP7/2007-2013, 286213, 2007-2013, FP7/2007, 248778, 115372
IN
Institut National de la Santé et de la Recherche Médicale
VU
Vrije Universiteit Amsterdam
Award: FP7/2007-2013
BF
Bundesministerium für Bildung und Forschung
Awards: 01GI0102, 01GI0711, 01GI0420
AS
Austrian Science Fund
Award: P13180
EM
Erasmus Medisch Centrum
NO
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Awards: VICI 453-14-005, NWO VICI 453-14-005, 480-05-003, FP7/2007-2013, 453-14-005
UO
University of Toronto
ON
Oesterreichische Nationalbank
ÖF
Österreichische Forschungsförderungsgesellschaft
Award: 827462
NF
Norges Forskningsråd
Awards: 223273, 213837, 237250, 248778, 251134, 225989
KG
Karl-Franzens-Universität Graz
MU
Medizinische Universität Graz
H
Hjartavernd
Award: N01-AG-12100
NF
Nasjonalforeningen for Folkehelsen
CH
Centre hospitalier régional universitaire de Lille
NI
National Institutes of Health
Awards: U01 AG032984, HHSN268201100012C, 2U01HL096812, AG032984, HL105756, FP7/2007-2013, HHSN268201100008C, HHSN268201100006C, 223273, 2U01HL096917, HHSN268201100007C, U01 AG016976, HHSN268201100011C, U01 2U01HL096812, AG016976, HHSN268201100010C, N01-AG-12100, HHSN268201100009C, U24 AG021886, HHSN268201100005C, 2U01HL096902, 2U01HL096814, 2U01HL096899, AG021886, 213837, R01 AG033193, NIA AG081220
MR
Medical Research Council
Awards: MR/K006584/1, 503480, MR/P021573/1, K006584/1, MC_PC_17228, MR/L011859/1, MC_PC_17214
NI
National Institute on Aging
Awards: R01 AG033193, U01 AG016976, AG081220, 2U01HL096917, 2U01HL096899, U01 AG032984, NIA AG081220, N01-AG-12100, AG033193, U01 2U01HL096812, 2U01HL096814, AG032984, 2U01HL096902, AG016976, U24 AG021886, AG021886
NH
National Heart, Lung, and Blood Institute
Awards: HHSN268201100007C, HHSN268201100009C, 2U01HL096899, HHSN268201100011C, HHSN268201100008C, 2U01HL096812, 2U01HL096917, RC2HL102419, HHSN268201100006C, HL105756, U01 2U01HL096812, HHSN268201100005C, HHSN268201100010C, R01 HL105756, 2U01HL096814, AG033193, 2U01HL096902, HHSN268201100012C
NI
National Institute on Deafness and Other Communication Disorders
Awards: 2U01HL096917, 2U01HL096899, U01 2U01HL096812, 2U01HL096814, 2U01HL096902
NI
National Institute of Neurological Disorders and Stroke
Awards: 2U01HL096814, 2U01HL096917, U01 2U01HL096812, HHSN268201100005C, 2U01HL096899, 2U01HL096902, 2U01HL096812