reviewJournal of the American College of CardiologyJan 1, 2019HYBRID OA

Multitarget Strategies to Reduce Myocardial Ischemia/Reperfusion Injury

SMSean M. DavidsonPFPéter FerdinandyIAIoanna AndreadouHEHans Erik BøtkerGHGerd Heusch

University College London · Semmelweis University · +17 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Many treatments have been identified that confer robust cardioprotection in experimental animal models of acute ischemia and reperfusion injury. However, translation of these cardioprotective therapies into the clinical setting of acute myocardial infarction (AMI) for patient benefit has been disappointing. One important reason might be that AMI is multifactorial, causing cardiomyocyte death via multiple mechanisms, as well as affecting other cell types, including platelets, fibroblasts, endothelial and smooth muscle cells, and immune cells. Many cardioprotective strategies act through common end-effectors and may be suboptimal in patients with comorbidities. In this regard, emerging data suggest that optimal…

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678
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56.46
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100%
References
68
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Authors

11

Topics & keywords

Topics
Keywords
  • Cardioprotection
  • Medicine
  • Reperfusion injury
  • Myocardial infarction
  • Ischemia
  • Cardiology
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