Nanotechnology-based antimicrobials and delivery systems for biofilm-infection control
University Medical Center Groningen · University of Groningen · +5 more institutions
Abstract
Bacterial-infections are mostly due to bacteria in an adhering, biofilm-mode of growth and not due to planktonically growing, suspended-bacteria. Biofilm-bacteria are much more recalcitrant to conventional antimicrobials than planktonic-bacteria due to (1) emergence of new properties of biofilm-bacteria that cannot be predicted on the basis of planktonic properties, (2) low penetration and accumulation of antimicrobials in a biofilm, (3) disabling of antimicrobials due to acidic and anaerobic conditions prevailing in a biofilm, and (4) enzymatic modification or inactivation of antimicrobials by biofilm inhabitants. In recent years, new nanotechnology-based antimicrobials have been designed to kill planktonic,…
Citation impact
- FWCI
- 28.28
- Percentile
- 100%
- References
- 53
Authors
7- YLYong Liu
University Medical Center Groningen, University of Groningen, Nankai University, State Key Laboratory of Chemical Engineering, State Key Laboratory of Medicinal Chemical Biology
- LSLinqi ShiCorresponding
Nankai University, Collaborative Innovation Center of Chemical Science and Engineering Tianjin, State Key Laboratory of Chemical Engineering, State Key Laboratory of Medicinal Chemical Biology
- LSLinzhu Su
Nankai University, State Key Laboratory of Chemical Engineering, State Key Laboratory of Medicinal Chemical Biology
- HCHenny C. van der Mei
University Medical Center Groningen, University of Groningen
- PCPaul C. Jutte
University Medical Center Groningen, University of Groningen, Dialyse Centrum Groningen
Topics & keywords
- Biofilm
- Antimicrobial
- Nanotechnology
- Microbiology
- Bacteria
- Biology
- Materials science