Enhanced Activity of Enzymes Encapsulated in Hydrophilic Metal–Organic Frameworks
The University of Adelaide · Fudan University · +3 more institutions
Abstract
Encapsulation of biomacromolecules in metal-organic frameworks (MOFs) can preserve biological functionality in harsh environments. Despite the success of this approach, termed biomimietic mineralization, limited consideration has been given to the chemistry of the MOF coating. Here, we show that enzymes encapsulated within hydrophilic MAF-7 or ZIF-90 retain enzymatic activity upon encapsulation and when exposed to high temperatures, denaturing or proteolytic agents, and organic solvents, whereas hydrophobic ZIF-8 affords inactive catalase and negligible protection to urease.
Citation impact
- FWCI
- 21.47
- Percentile
- 100%
- References
- 41
Authors
14- WLWeibin Liang
The University of Adelaide
- HXHuoshu Xu
Fudan University, Collaborative Innovation Center of Chemistry for Energy Materials
- FCFrancesco Carraro
Graz University of Technology
- NKNatasha K. Maddigan
The University of Adelaide
- QLQiaowei Li
Fudan University, Collaborative Innovation Center of Chemistry for Energy Materials
Topics & keywords
- Chemistry
- Urease
- Metal-organic framework
- Mineralization (soil science)
- Enzyme
- Encapsulation (networking)
- Coating
- Catalase