Nanoparticle‐Enhanced Radiotherapy to Trigger Robust Cancer Immunotherapy

Abstract External radiotherapy is extensively used in clinic to destruct tumors by locally applied ionizing‐radiation beams. However, the efficacy of radiotherapy is usually limited by tumor hypoxia‐associated radiation resistance. Moreover, as a local treatment technique, radiotherapy can hardly control tumor metastases, the major cause of cancer death. Herein, core–shell nanoparticles based poly(lactic‐ co ‐glycolic) acid (PLGA) are fabricate, by encapsulating water‐soluble catalase (Cat), an enzyme that can decompose H 2 O 2 to generate O 2 , inside the inner core, and loading hydrophobic imiquimod (R837), a Toll‐like‐receptor‐7 agonist, within the PLGA shell. The formed PLGA‐R837@Cat nanoparticles can…

• NN
  National Natural Science Foundation of China

  Awards: 51525203, 51761145041
• NK
  National Key Research and Development Program of China

  Award: 2016YFA0201200