Cellular Senescence: Aging, Cancer, and Injury
Veneto Institute of Molecular Medicine · Institute of Oncology Research · +2 more institutions
Abstract
Cellular senescence is a permanent state of cell cycle arrest that occurs in proliferating cells subjected to different stresses. Senescence is, therefore, a cellular defense mechanism that prevents the cells to acquire an unnecessary damage. The senescent state is accompanied by a failure to re-enter the cell cycle in response to mitogenic stimuli, an enhanced secretory phenotype and resistance to cell death. Senescence takes place in several tissues during different physiological and pathological processes such as tissue remodeling, injury, cancer, and aging. Although senescence is one of the causative processes of aging and it is responsible of aging-related disorders, senescent cells can also play a…
Citation impact
- FWCI
- 56.28
- Percentile
- 100%
- References
- 369
Authors
6- ACArianna CalcinottoCorresponding
Veneto Institute of Molecular Medicine, Institute of Oncology Research, Università della Svizzera italiana, University of Lausanne
- JKJaskaren Kohli
Veneto Institute of Molecular Medicine, Institute of Oncology Research, Università della Svizzera italiana, University of Lausanne
- EZElena Zagato
Veneto Institute of Molecular Medicine, Institute of Oncology Research, Università della Svizzera italiana, University of Lausanne
- LPLaura Pellegrini
Veneto Institute of Molecular Medicine, Institute of Oncology Research, Università della Svizzera italiana, University of Lausanne
- MDMarco Demaria
Veneto Institute of Molecular Medicine, Institute of Oncology Research, Università della Svizzera italiana, University of Lausanne
Topics & keywords
- Senescence
- Cell biology
- Carcinogenesis
- Biology
- Cell cycle checkpoint
- Cancer
- Cell cycle
- Cell
- Good health and well-being