Applications of Deuterium in Medicinal Chemistry

The use of deuteration in medicinal chemistry has exploded in the past years, and the FDA has recently approved the first deuterium-labeled drug. Precision deuteration goes beyond the pure and simple amelioration of the pharmacokinetic parameters of a drug and might provide an opportunity when facing problems in terms of metabolism-mediated toxicity, drug interactions, and low bioactivation. The use of deuterium is even broader, offering the opportunity to lower the degree of epimerization, reduce the dose of coadministered boosters, and discover compounds where deuterium is the basis for the mechanism of action. Nevertheless, designing, synthesizing, and developing a successful deuterated drug is far from…

• FC
  Fondazione Cariplo
• AI
  Associazione Italiana per la Ricerca sul Cancro

  Awards: 22568, 15918
• UD
  Università degli Studi del Piemonte Orientale