Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

Linnér, Richard Karlsson; Biroli, Pietro; Kong, Edward; Meddens, S. Fleur W.; Wedow, Robbee; Fontana, Mark Alan; Lebreton, Maël P.; Tino, Stephen P.; Abdellaoui, Abdel; Hammerschlag, Anke R.; Nivard, Michel G.; Okbay, Aysu; Rietveld, Cornelius A.; Timshel, Pascal; Trzaskowski, Maciej; Vlaming, Ronald de; Zünd, Christian; Bao, Yanchun; Buzdugan, Laura; Caplin, Ann H.; Chen, Chia‐Yen; Eibich, Peter; Fontanillas, Pierre; González, Juan R.; Joshi, Peter K.; Karhunen, Ville; Kleinman, Aaron; Levin, Remy Z.; Lill, Christina M.; Meddens, Gerardus A.; Muntané, Gerard; Sanchez‐Roige, Sandra; Rooij, Frank J.A. van; Taskesen, Erdogan; Wu, Yang; Zhang, Futao; Auton, Adam; Boardman, Jason D.; Clark, David W.; Conlin, Andrew; Dolan, Conor; Fischbacher, Urs; Groenen, Patrick J. F.; Harris, Kathleen Mullan; Hasler, Gregor; Hofman, Albert; Ikram, M. Arfan; Jain, Sonia; Karlsson, Robert; Kessler, Ronald C.; Kooyman, Maarten; MacKillop, James; Männikkö, Minna; Morcillo-Suárez, Carlos; McQueen, Matthew B.; Schmidt, Klaus M.; Smart, Melissa; Sutter, Matthias; Thurik, Roy; Uitterlinden, André G.; White, Jon; Wit, Harriet de; Yang, Jian; Bertram, Lars; Boomsma, Dorret I.; Esko, Tõnu; Fehr, Ernst; Hinds, David A.; Johannesson, Magnus; Kumari, Meena; Laibson, David; Magnusson, Patrik K. E.; Meyer, Michelle N.; Navarro, Arcadi; Palmer, Abraham A.; Pers, Tune H.; Posthuma, Daniëlle; Schunk, Daniel; Stein, Murray B.; Svento, Rauli; Tiemeier, Henning; Timmers, Paul R. H. J.; Turley, Patrick; Ursano, Robert J.; Wagner, Gert G.; Wilson, James F.; Gratten, Jacob; Lee, James J.; Cesarini, David; Benjamin, Daniel J.; Koellinger, Philipp; Beauchamp, Jonathan

doi:10.1038/s41588-018-0309-3

reviewNature GeneticsJan 9, 2019GREEN OA

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

RKRichard Karlsson Linnér PBPietro Biroli EKEdward Kong SFS. Fleur W. Meddens RWRobbee Wedow

Amsterdam Neuroscience · Cognitive Research (United States) · +70 more institutions

PubMed

Indexed incrossrefdatacitepubmed

Abstract

No abstract available for this paper.

Citation impact

838

total citations

FWCI: 82.58
Percentile: 100%
References: 56

Citations per year

Authors

RK
Richard Karlsson LinnérCorresponding
Amsterdam Neuroscience, Cognitive Research (United States), Vrije Universiteit Amsterdam, Amsterdam UMC Location Vrije Universiteit Amsterdam, Erasmus University Rotterdam
PB
Pietro Biroli
University of Zurich
EK
Edward Kong
Harvard University
SF
S. Fleur W. Meddens
Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Erasmus University Rotterdam
RW
Robbee Wedow
Broad Institute, Harvard University, Massachusetts General Hospital

Topics & keywords

Topics

Genetic Associations and Epidemiology100%
Cognitive Abilities and Testing96%
Genetic Mapping and Diversity in Plants and Animals95%

Keywords

Biology
Genome-wide association study
Genetics
Association (psychology)
Genetic association
Evolutionary biology
Single-nucleotide polymorphism
Genotype

UN Sustainable Development Goals

Good health and well-being

No related works found for this paper.

Funding

S
Sanofi
UO
University of Southern California
GC
Genome Canada
Award: OGI-152
OG
Ontario Genomics
OP
Open Philanthropy Project
GO
Government of Canada
OG
Ontario Genomics Institute
V
Vetenskapsrådet
Award: 421-2013-1061
NI
National Institutes of Health
Award: R01-AG042568
SS
Social Sciences and Humanities Research Council of Canada
Award: 11425
MR
Medical Research Council
Awards: 1811434, 1805084, MR/N01104X/1, MR/K026992/1, MR/N01104X/2, MC_UU_00007/10
BA
Biotechnology and Biological Sciences Research Council
Awards: BB/F022441/1, BB/F019394/1
EA
Economic and Social Research Council
Awards: ES/N00812X/1, ES/M008592/1, ES/S008349/1
NI
National Institute on Aging
Awards: P30-AG012810, T32-AG000186, R01-AG042568, AG005842, P01-AG005842