Tau PET imaging in neurodegenerative tauopathies—still a challenge

Leuzy, Antoine; Chiotis, Konstantinos; Lemoine, Laëtitia; Gillberg, Per‐Göran; Almkvist, Ove; Rodriguez‐Vieitez, Elena; Nordberg, Agneta

doi:10.1038/s41380-018-0342-8

reviewMolecular PsychiatryJan 11, 2019HYBRID OA

Tau PET imaging in neurodegenerative tauopathies—still a challenge

ALAntoine Leuzy KCKonstantinos Chiotis LLLaëtitia Lemoine PGPer‐Göran Gillberg OAOve Almkvist

Karolinska Institutet · Karolinska University Hospital · +1 more institution

PubMed

Indexed incrossrefpubmed

Abstract

The accumulation of pathological misfolded tau is a feature common to a collective of neurodegenerative disorders known as tauopathies, of which Alzheimer's disease (AD) is the most common. Related tauopathies include progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), Down's syndrome (DS), Parkinson's disease (PD), and dementia with Lewy bodies (DLB). Investigation of the role of tau pathology in the onset and progression of these disorders is now possible due the recent advent of tau-specific ligands for use with positron emission tomography (PET), including first-(e.g., [ 18 F] THK5317, [ 18 F]THK5351, [ 18 F]AV1451, and [ 11 C]PBB3) and second-generation compounds [namely [ 18 F]MK-6240, […

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Keywords

Progressive supranuclear palsy
Corticobasal degeneration
Dementia with Lewy bodies
Neurodegeneration
Neuroscience
Positron emission tomography
Dementia
Pittsburgh compound B

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