Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway

The importance of gut microbiota in human health and pathophysiology is undisputable. Despite the abundance of metagenomics data, the functional dynamics of gut microbiota in human health and disease remain elusive. Urolithin A (UroA), a major microbial metabolite derived from polyphenolics of berries and pomegranate fruits displays anti-inflammatory, anti-oxidative, and anti-ageing activities. Here, we show that UroA and its potent synthetic analogue (UAS03) significantly enhance gut barrier function and inhibit unwarranted inflammation. We demonstrate that UroA and UAS03 exert their barrier functions through activation of aryl hydrocarbon receptor (AhR)- nuclear factor erythroid 2-related factor 2…

• KI
  Kentucky IDeA Networks of Biomedical Research Excellence

  Award: P20GM103436
• DO
  Department of Biotechnology, Ministry of Science and Technology, India
• DO
  Department of Science and Technology, Ministry of Science and Technology, India
• NI
  National Institutes of Health

  Awards: P20GM125504, P30GM106396, P20GM103436, NIH P20GM103436, P20GM125504-01
• NC
  National Centre for Biological Sciences
• NC
  National Cancer Institute

  Awards: CA191683, R21CA216090
• NI
  National Institute of General Medical Sciences

  Awards: P20GM125504, P20GM103436, P20GM125504-01, P30GM106396