Toward Multi-Targeted Platinum and Ruthenium Drugs—A New Paradigm in Cancer Drug Treatment Regimens?
Royal College of Surgeons in Ireland
Abstract
While medicinal inorganic chemistry has been practised for over 5000 years, it was not until the late 1800s when Alfred Werner published his ground-breaking research on coordination chemistry that we began to truly understand the nature of the coordination bond and the structures and stereochemistries of metal complexes. We can now readily manipulate and fine-tune their properties. This had led to a multitude of complexes with wide-ranging biomedical applications. This review will focus on the use and potential of metal complexes as important therapeutic agents for the treatment of cancer. With major advances in technologies and a deeper understanding of the human genome, we are now in a strong position to…
Citation impact
- FWCI
- 35.27
- Percentile
- 100%
- References
- 477
Authors
2Topics & keywords
- Chemistry
- Nanotechnology
- Anticancer drug
- Drug discovery
- Ruthenium
- Drug
- Combinatorial chemistry
- Pharmacology
- Good health and well-being