Computational Modeling of Realistic Cell Membranes

Marrink, ‪Siewert J.; Corradi, Valentina; Souza, Paulo C. T.; Ingólfsson, Helgi I.; Tieleman, D. Peter; Sansom, Mark S.P.

doi:10.1021/acs.chemrev.8b00460

reviewChemical ReviewsJan 9, 2019HYBRID OA

Computational Modeling of Realistic Cell Membranes

‪J‪Siewert J. Marrink VCValentina Corradi PCPaulo C. T. Souza HIHelgi I. Ingólfsson DPD. Peter Tieleman

University of Groningen · University of Calgary · +2 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Cell membranes contain a large variety of lipid types and are crowded with proteins, endowing them with the plasticity needed to fulfill their key roles in cell functioning. The compositional complexity of cellular membranes gives rise to a heterogeneous lateral organization, which is still poorly understood. Computational models, in particular molecular dynamics simulations and related techniques, have provided important insight into the organizational principles of cell membranes over the past decades. Now, we are witnessing a transition from simulations of simpler membrane models to multicomponent systems, culminating in realistic models of an increasing variety of cell types and organelles. Here, we review…

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Topics

Keywords

Membrane
Chemistry
Variety (cybernetics)
Organelle
Biochemical engineering
Nanotechnology
Computational model
Field (mathematics)

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