Vascular dysfunction—The disregarded partner of Alzheimer's disease

Sweeney, Melanie D.; Montagne, Axel; Sagare, Abhay P.; Nation, Daniel A.; Schneider, Lon S.; Chui, Helena C.; Harrington, Michael G.; Pa, Judy; Law, Meng; Wang, Danny J.J.; Jacobs, Russell E.; Doubal, Fergus; Ramirez, Joel; Black, Sandra E.; Nedergaard, Maiken; Benveniste, Helene; Dichgans, Martin; Iadecola, Costantino; Love, Seth; Bath, Philip M.; Markus, Hugh S.; Salman, Rustam Al‐Shahi; Allan, Stuart M.; Quinn, Terence J.; Kalaria, Rajesh N.; Werring, David J.; Carare, Roxana O.; Touyz, Rhian M.; Williams, Steven; Moskowitz, Michael A.; Katušić, Zvonimir S.; Lutz, Sarah E.; Lazarov, Orly; Minshall, Richard D.; Rehman, Jalees; Davis, Thomas P.; Wellington, Cheryl L.; González, Hector M.; Yuan, Chun; Lockhart, Samuel N.; Hughes, Timothy M.; Chen, Christopher; Sachdev, Perminder S.; O’Brien, John T.; Skoog, Ingmar; Pantoni, Leonardo; Gustafson, Deborah; Biessels, Geert Jan; Wallin, Anders; Smith, Eric E.; Mok, Vincent; Wong, Adrian; Passmore, Peter; Barkof, Frederick; Muller, Majon; Breteler, Monique M.B.; Román, Gustavo C.; Hamel, Édith; Seshadri, Sudha; Gottesman, Rebecca F.; Buchem, Mark A. van; Arvanitakis, Zoe; Schneider, Julie A.; Drewes, Lester R.; Hachinski, Vladimir; Finch, Caleb E.; Toga, Arthur W.; Wardlaw, Joanna M.; Zloković, Berislav V.

doi:10.1016/j.jalz.2018.07.222

articleAlzheimer s & DementiaJan 1, 2019GREEN OA

Vascular dysfunction—The disregarded partner of Alzheimer's disease

MDMelanie D. Sweeney AMAxel Montagne APAbhay P. Sagare DADaniel A. Nation LSLon S. Schneider

University of Southern California · Huntington Medical Research Institutes · +75 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Increasing evidence recognizes Alzheimer's disease (AD) as a multifactorial and heterogeneous disease with multiple contributors to its pathophysiology, including vascular dysfunction. The recently updated AD Research Framework put forth by the National Institute on Aging-Alzheimer's Association describes a biomarker-based pathologic definition of AD focused on amyloid, tau, and neuronal injury. In response to this article, here we first discussed evidence that vascular dysfunction is an important early event in AD pathophysiology. Next, we examined various imaging sequences that could be easily implemented to evaluate different types of vascular dysfunction associated with, and/or contributing to, AD…

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716

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Topics & keywords

Topics

Keywords

Pathophysiology
Disease
Dementia
Medicine
Biomarker
Vascular dementia
Neuroscience
Cerebral blood flow

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