articleJournal of the American Chemical SocietyJan 11, 2019Closed access

Rational Design of Near-Infrared Aggregation-Induced-Emission-Active Probes: In Situ Mapping of Amyloid-β Plaques with Ultrasensitivity and High-Fidelity

WFWei FuCYChenxu YanZGZhiqian GuoJZJingjing ZhangHZHaiyan Zhang

East China University of Science and Technology · Chinese Academy of Sciences · +1 more institution

PubMed
Indexed incrossrefpubmed

Abstract

High-fidelity mapping of amyloid-β (Aβ) plaques is critical for the early detection of Alzheimer’s disease. However, in vivo probing of Aβ plaques by commercially available thioflavin derivatives (ThT or ThS) has proven to be extremely limited, as evident by the restriction of enrichment quenching effect, low signal-to-noise (S/N) ratio, and poor blood–brain barrier (BBB) penetrability. Herein, we demonstrate a rational design strategy of near-infrared (NIR) aggregation-induced emission (AIE)-active probes for Aβ plaques, through introducing a lipophilic π-conjugated thiophene-bridge for extension to NIR wavelength range with enhancement of BBB penetrability, and tuning the substituted position of the…

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Topics & keywords

Topics
Keywords
  • Chemistry
  • Rational design
  • Thioflavin
  • In vivo
  • Fluorescence
  • Biophysics
  • Stokes shift
  • Conjugated system
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