reviewInternational Journal of Molecular SciencesJan 17, 2019GOLD OA

Gut-Liver Axis, Gut Microbiota, and Its Modulation in the Management of Liver Diseases: A Review of the Literature

IMIvana MiloševićAVAnkica VujovićABAleksandra BaraćMDMarina DjelićMKMiloš Korać

University of Belgrade · Center for Health, Exercise and Sport Sciences · +2 more institutions

PubMed
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Abstract

The rapid scientific interest in gut microbiota (GM) has coincided with a global increase in the prevalence of infectious and non-infectivous liver diseases. GM, which is also called "the new virtual metabolic organ", makes axis with a number of extraintestinal organs, such as kidneys, brain, cardiovascular, and the bone system. The gut-liver axis has attracted greater attention in recent years. GM communication is bi-directional and involves endocrine and immunological mechanisms. In this way, gut-dysbiosis and composition of "ancient" microbiota could be linked to pathogenesis of numerous chronic liver diseases such as chronic hepatitis B (CHB), chronic hepatitis C (CHC), alcoholic liver disease (ALD),…

Citation impact

524
total citations
FWCI
18.03
Percentile
100%
References
106
Citations per year

Authors

12

Topics & keywords

Topics
Keywords
  • Fatty liver
  • Steatohepatitis
  • Gut flora
  • Hepatocellular carcinoma
  • Cirrhosis
  • Chronic liver disease
  • Dysbiosis
  • Medicine
UN Sustainable Development Goals
  • Good health and well-being
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