Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors

The NLRP3 inflammasome is a multimeric protein complex that initiates an inflammatory form of cell death and triggers the release of proinflammatory cytokines IL-1β and IL-18. The NLRP3 inflammasome has been implicated in a wide range of diseases, including Alzheimer's disease, Prion diseases, type 2 diabetes, and some infectious diseases. It has been found that a variety of stimuli including danger-associated molecular patterns (DAMPs, such as silica and uric acid crystals) and pathogen-associated molecular patterns (PAMPs) can activate NLRP3 inflammasome, but the specific regulatory mechanisms of NLRP3 inflammasome activation remain unclear. Understanding the mechanisms of NLRP3 activation will enable the…

• NN
  National Natural Science Foundation of China

  Award: 31502034
• ZA
  Zhejiang A and F University
• FR
  Fundamental Research Funds for the Central Universities
• NS
  Natural Science Foundation of Zhejiang Province

  Awards: LY18C180001, LQ15C180002