Singlet Molecular Oxygen Reactions with Nucleic Acids, Lipids, and Proteins

Mascio, Paolo Di; Martinez, Gláucia Regina; Miyamoto, Sayuri; Ronsein, Graziella E.; Medeiros, Marisa Helena Gennari de; Cadet, Jean

doi:10.1021/acs.chemrev.8b00554

reviewChemical ReviewsFeb 5, 2019GREEN OA

Singlet Molecular Oxygen Reactions with Nucleic Acids, Lipids, and Proteins

PDPaolo Di Mascio GRGláucia Regina Martinez SMSayuri Miyamoto GEGraziella E. Ronsein MHMarisa Helena Gennari de Medeiros

Universidade de São Paulo · Universidade Federal do Paraná · +1 more institution

PubMed

Indexed incrossrefpubmed

Abstract

Singlet oxygen (1O2) is a biologically relevant reactive oxygen species capable of efficiently reacting with cellular constituents. The resulting oxidatively generated damage to nucleic acids, membrane unsaturated lipids, and protein components has been shown to be implicated in several diseases, including arthritis, cataracts, and skin cancer. Singlet oxygen may be endogenously produced, among various possibilities, by myeloperoxidase, an enzyme implicated in inflammation processes, and also efficiently in skin by the UVA component of solar radiation through photosensitization reactions. Emphasis is placed in this Review on the description of the main oxidation reactions initiated by 1O2 and the resulting…

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Topics & keywords

Topics

Keywords

Chemistry
Singlet oxygen
Nucleic acid
Cycloaddition
Biomolecule
Dioxetane
Reactive intermediate
Biochemistry

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