reviewGenesJan 30, 2019GOLD OA

Eukaryotic 5-methylcytosine (m5C) RNA Methyltransferases: Mechanisms, Cellular Functions, and Links to Disease

KEKatherine E. BohnsackCHClaudia HöbartnerMTMarkus T. Bohnsack

Universitätsmedizin Göttingen · University of Göttingen · +1 more institution

PubMed
Indexed incrossrefdoajpubmed

Abstract

5-methylcytosine (m⁵C) is an abundant RNA modification that's presence is reported in a wide variety of RNA species, including cytoplasmic and mitochondrial ribosomal RNAs (rRNAs) and transfer RNAs (tRNAs), as well as messenger RNAs (mRNAs), enhancer RNAs (eRNAs) and a number of non-coding RNAs. In eukaryotes, C5 methylation of RNA cytosines is catalyzed by enzymes of the NOL1/NOP2/SUN domain (NSUN) family, as well as the DNA methyltransferase homologue DNMT2. In recent years, substrate RNAs and modification target nucleotides for each of these methyltransferases have been identified, and structural and biochemical analyses have provided the first insights into how each of these enzymes achieves target…

Citation impact

520
total citations
FWCI
18.03
Percentile
100%
References
88
Citations per year

Authors

3

Topics & keywords

Topics
Keywords
  • Methyltransferase
  • Biology
  • RNA
  • Small nucleolar RNA
  • Transfer RNA
  • Non-coding RNA
  • 5-Methylcytosine
  • Methylation
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