An introduction to chimeric antigen receptor (CAR) T‐cell immunotherapy for human cancer

Chimeric antigen receptor (CAR) T-cell therapy represents a major advancement in personalized cancer treatment. In this strategy, a patient's own T cells are genetically engineered to express a synthetic receptor that binds a tumor antigen. CAR T cells are then expanded for clinical use and infused back into the patient's body to attack and destroy chemotherapy-resistant cancer. Dramatic clinical responses and high rates of complete remission have been observed in the setting of CAR T-cell therapy of B-cell malignancies. This resulted in two recent FDA approvals of CAR T cells directed against the CD19 protein for treatment of acute lymphoblastic leukemia and diffuse large B-cell lymphoma. Thus, CAR T cells…

• GA
  Gabrielle's Angel Foundation for Cancer Research
• PI
  Parker Institute for Cancer Immunotherapy
• NC
  National Cancer Institute

  Awards: P01CA214278, P01CA214278‐01