Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape

Tumor immune escape is an important strategy of tumor survival. There are many mechanisms of tumor immune escape, including immunosuppression, which has become a research hotspot in recent years. The programmed death ligand-1/programmed death-1 (PD-L1/PD-1) signaling pathway is an important component of tumor immunosuppression, which can inhibit the activation of T lymphocytes and enhance the immune tolerance of tumor cells, thereby achieving tumor immune escape. Therefore, targeting the PD-L1/PD-1 pathway is an attractive strategy for cancer treatment; however, the therapeutic effectiveness of PD-L1/PD-1 remains poor. This situation requires gaining a deeper understanding of the complex and varied molecular…

• NN
  National Natural Science Foundation of China

  Awards: 81702907, 81872278, 31741049, 2018SK21210, 2018JJ3815, 81672683, 81772928, 81672993, 81572787, 81772901, 21806186, 2018SK21211, 2018JJ3704, 111-2-12
• NS
  Natural Science Foundation of Hunan Province

  Awards: 2018JJ3704, 2016JC2035, 2018JJ3815, 2017SK2015
• HE
  Higher Education Discipline Innovation Project

  Awards: 111-2, 111-2-12
• OE
  Overseas Expertise Introduction Project for Discipline Innovation

  Awards: No. 111-2-12, 111 Project, 111-2-12, 111 Project, No. 111-2-12