The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice
The Affiliated Yongchuan Hospital of Chongqing Medical University · Children's Hospital of Chongqing Medical University · +5 more institutions
Abstract
Schizophrenia (SCZ) is a devastating mental disorder with poorly defined underlying molecular mechanisms. The gut microbiome can modulate brain function and behaviors through the microbiota-gut-brain axis. Here, we found that unmedicated and medicated patients with SCZ had a decreased microbiome α-diversity index and marked disturbances of gut microbial composition versus healthy controls (HCs). Several unique bacterial taxa (e.g., Veillonellaceae and Lachnospiraceae) were associated with SCZ severity. A specific microbial panel (Aerococcaceae, Bifidobacteriaceae, Brucellaceae, Pasteurellaceae, and Rikenellaceae) enabled discriminating patients with SCZ from HCs with 0.769 area under the curve. Compared to…
Citation impact
- FWCI
- 30.50
- Percentile
- 100%
- References
- 41
Authors
17- PZPeng ZhengCorresponding
The Affiliated Yongchuan Hospital of Chongqing Medical University, Children's Hospital of Chongqing Medical University, Chongqing Medical University
- BZBenhua ZengCorresponding
Army Medical University
- MLMeiling Liu
The Affiliated Yongchuan Hospital of Chongqing Medical University, Chongqing Medical University
- JCJianjun Chen
Chongqing Medical University
- JPJunxi Pan
Children's Hospital of Chongqing Medical University, Chongqing Medical University
Topics & keywords
- Schizophrenia (object-oriented programming)
- Glutamine
- Microbiome
- Glutamate receptor
- Gut microbiome
- Neuroscience
- Gut–brain axis
- Medicine
- Zero hunger