Symptom Subtypes of Obstructive Sleep Apnea Predict Incidence of Cardiovascular Outcomes

Mazzotti, Diego R.; Keenan, Brendan T; Lim, Diane C; Gottlieb, Daniel J.; Kim, Jinyoung; Pack, Allan I

doi:10.1164/rccm.201808-1509oc

articleAmerican Journal of Respiratory and Critical Care MedicineFeb 15, 2019Closed access

Symptom Subtypes of Obstructive Sleep Apnea Predict Incidence of Cardiovascular Outcomes

DRDiego R. Mazzotti BTBrendan T Keenan DCDiane C Lim DJDaniel J. Gottlieb JKJinyoung Kim

Circadian (United States) · SleepMed · +4 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Abstract Rationale Symptom subtypes have been described in clinical and population samples of patients with obstructive sleep apnea (OSA). It is unclear whether these subtypes have different cardiovascular consequences. Objectives To characterize OSA symptom subtypes and assess their association with prevalent and incident cardiovascular disease in the Sleep Heart Health Study. Methods Data from 1,207 patients with OSA (apnea–hypopnea index ≥ 15 events/h) were used to evaluate the existence of symptom subtypes using latent class analysis. Associations between subtypes and prevalence of overall cardiovascular disease and its components (coronary heart disease, heart failure, and stroke) were assessed using…

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Topics & keywords

Topics

Keywords

Medicine
Internal medicine
Heart failure
Hazard ratio
Obstructive sleep apnea
Proportional hazards model
Sleep apnea
Cardiology

UN Sustainable Development Goals

Good health and well-being

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