Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates

Abstract Sleep is an essential state of decreased activity and alertness but molecular factors regulating sleep duration remain unknown. Through genome-wide association analysis in 446,118 adults of European ancestry from the UK Biobank, we identify 78 loci for self-reported habitual sleep duration ( p < 5 × 10 −8 ; 43 loci at p < 6 × 10 −9 ). Replication is observed for PAX8 , VRK2 , and FBXL12/UBL5/PIN1 loci in the CHARGE study ( n = 47,180; p < 6.3 × 10 −4 ), and 55 signals show sign-concordant effects. The 78 loci further associate with accelerometer-derived sleep duration, daytime inactivity, sleep efficiency and number of sleep bouts in secondary analysis ( n = 85,499). Loci are enriched for…

• AT
  American Thoracic Society

  Award: K01-HL135405
• WT
  Wellcome Trust

  Awards: 107849/Z/15/Z, 107849, /Z/15/Z, 104150, WT097835MF
• DR
  Diabetes Research and Wellness Foundation
• UO
  University of Manchester
• NN
  Novo Nordisk
• NI
  National Institutes of Health

  Awards: R01 DK102696, R01DK107859, R01-HL113338, R01DK105072, U01HL53941, R35-HL135818, NIDDK R01DK105072, N01-HC-25195, NIH R01
• MR
  Medical Research Council

  Awards: MR/M005070/1, MR/P012167/1, MR/M005070/1, MC_UU_00011/2, MC_UU_00011/6, MR/P023576/2, WT097835MF
• NH
  National Heart, Lung, and Blood Institute

  Awards: N02-HL-6-4278, R01DK105072, HL113338, R01-HL113338, N01-HC-25195, HL135818, U01HL53941, NIH R01, R35-HL135818
• NI
  National Institute of Diabetes and Digestive and Kidney Diseases

  Awards: N01-HC-25195, F32DK102323, R01DK105072, NIDDK R01DK105072, R01 DK102696, NIH R01, R01DK107859
• FI
  FP7 Ideas: European Research Council

  Award: 323195