The Role of Voltage-Gated Sodium Channels in Pain Signaling
Yale University · University of Oxford · +1 more institution
Abstract
Acute pain signaling has a key protective role and is highly evolutionarily conserved. Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease, and is associated with sensitization of the somatosensory nervous system. Primary sensory neurons are involved in both of these processes, and the recent advances in understanding sensory transduction and human genetics are the focus of this review. Voltage-gated sodium channels (VGSCs) are important determinants of sensory neuron excitability: they are essential for the initial transduction of sensory stimuli, the electrogenesis of the action potential, and neurotransmitter release from sensory neuron terminals. Na v 1.1, Na v 1.6, Na v…
Citation impact
- FWCI
- 38.75
- Percentile
- 100%
- References
- 518
Authors
5- DBDavid BennettCorresponding
Yale University, University of Oxford, VA Connecticut Healthcare System
- ACAlex Clark
Yale University, University of Oxford, VA Connecticut Healthcare System
- JHJianying Huang
Yale University, University of Oxford, VA Connecticut Healthcare System
- SGStephen G. Waxman
Yale University, University of Oxford, VA Connecticut Healthcare System
- SDSulayman D. Dib‐Hajj
Yale University, University of Oxford, VA Connecticut Healthcare System
Topics & keywords
- Sensory system
- Neuroscience
- Sensory neuron
- Sodium channel
- Transduction (biophysics)
- Sensitization
- Chronic pain
- Nociceptor
- Good health and well-being