Chaperone-mediated autophagy is involved in the execution of ferroptosis
Chinese Academy of Sciences · Shanghai Institute of Organic Chemistry · +2 more institutions
Abstract
Necroptosis and ferroptosis are two distinct necrotic cell death modalities with no known common molecular mechanisms. Necroptosis is activated by ligands of death receptors such as tumor necrosis factor-α (TNF-α) under caspase-deficient conditions, whereas ferroptosis is mediated by the accumulation of lipid peroxides upon the depletion/or inhibition of glutathione peroxidase 4 (GPX4). The molecular mechanism that mediates the execution of ferroptosis remains unclear. In this study, we identified 2-amino-5-chloro-N,3-dimethylbenzamide (CDDO), a compound known to inhibit heat shock protein 90 (HSP90), as an inhibitor of necroptosis that could also inhibit ferroptosis. We found that HSP90 defined a common…
Citation impact
- FWCI
- 19.48
- Percentile
- 100%
- References
- 71
Authors
9- ZWZheming WuCorresponding
Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences
- YGYang Geng
Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry
- XLXiaojuan Lu
Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry
- YSYuying Shi
Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry
- GWGuowei Wu
Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences
Topics & keywords
- Necroptosis
- Autophagy
- Chaperone (clinical)
- Programmed cell death
- Hsp90
- Cell biology
- Biology
- Heat shock protein
- Good health and well-being