Treatment Combinations for Alzheimer’s Disease: Current and Future Pharmacotherapy Options

Although Alzheimer's disease (AD) is the world's leading cause of dementia and the population of patients with AD continues to grow, no new therapies have been approved in more than a decade. Many clinical trials of single-agent therapies have failed to affect disease progression or symptoms compared with placebo. The complex pathophysiology of AD may necessitate combination treatments rather than monotherapy. The goal of this narrative literature review is to describe types of combination therapy, review the current clinical evidence for combination therapy regimens (both symptomatic and disease-modifying) in the treatment of AD, describe innovative clinical trial study designs that may be effective in…

• HL
  H. Lundbeck A/S

  Award: P20GM109025
• NI
  National Institutes of Health

  Award: P20GM109025