reviewInternational Journal of Molecular SciencesFeb 15, 2019GOLD OA

Targeting Tumor Microenvironment for Cancer Therapy

CRCatarina Roma‐RodriguesRMRita MendesPVPedro V. BaptistaARAlexandra R. Fernandes

Universidade Nova de Lisboa

PubMed
Indexed incrossrefdoajpubmed

Abstract

Cancer development is highly associated to the physiological state of the tumor microenvironment (TME). Despite the existing heterogeneity of tumors from the same or from different anatomical locations, common features can be found in the TME maturation of epithelial-derived tumors. Genetic alterations in tumor cells result in hyperplasia, uncontrolled growth, resistance to apoptosis, and metabolic shift towards anaerobic glycolysis (Warburg effect). These events create hypoxia, oxidative stress and acidosis within the TME triggering an adjustment of the extracellular matrix (ECM), a response from neighbor stromal cells (e.g., fibroblasts) and immune cells (lymphocytes and macrophages), inducing angiogenesis…

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Authors

4

Topics & keywords

Topics
Keywords
  • Tumor microenvironment
  • Cancer research
  • Stromal cell
  • Microvesicles
  • Angiogenesis
  • Immune system
  • Metastasis
  • Cancer cell
UN Sustainable Development Goals
  • Good health and well-being
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